Bipolar

2023 - 3 - 17

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Mindfulness-based cognitive therapy of benefit to select patients ... (MIMS General News (Hong Kong))

When added to standard treatment, mindfulness-based cognitive therapy (MBCT) may have favourable effects for patients with bipolar disorder and modera...

Moreover, 51 (71 percent) participants reported still practicing formal mindfulness exercises regularly at 3 months (mean frequency per week 3.5, mean minutes per week 21.0). They were randomly assigned to receive treatment as usual (TAU) alone (n=72) or in combination with MBCT (n=72). At 6 months, the number of participants who still practiced MBCT decreased to 37 (51 percent) participants (mean frequency per week 2.7, mean minutes per week 15.2), and this remained until 15 months. In the MBCT plus TAU group, participants who attended not more than four MBCT sessions (n=18) did not differ from those who completed MBCT. When added to standard treatment, mindfulness-based cognitive therapy (MBCT) may have favourable effects for patients with The study involved 144 participants (mean age was 46.6 years, 60 percent women) with bipolar disorder type I and II.

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Polygenic risk scores tied to episode polarity in bipolar disorder (MIMS General News (Hong Kong))

Polygenic risk scores (PRS) for bipolar disorder, major depression, and schizophrenia are predictive of episode polarity and psychotic symptoms in a s...

PRS for schizophrenia also positively correlated with any manic episodes (OR, 1.13, 95 percent CI, 1.01‒1.27), but only when psychotic symptoms were existing (OR for psychotic mania, 1.27, 95 percent CI, 1.05‒1.54; OR for nonpsychotic mania, 1.06, 95 percent CI, 0.93‒1.20). PRS for depression, on the other hand, showed a positive relationship with any depressive (OR, 1.11, 95 percent CI, 1.01‒1.23) and mixed (OR, 1.15, 95 percent CI, 1.03‒1.28) episodes and a negative interaction with any manic episodes (OR, 0.76, 96 percent CI, 0.69‒0.84). Finally, the authors explored the associations between PRS and polarity at first episode, polarity at any episode, and number of episodes with a given polarity for each disorder-specific PRS using logistic and negative binomial regression, adjusted for the other two PRSs, age, sex, genotype platform, and five ancestral principal components. Specifically, PRS for bipolar disorder positively correlated with any manic episodes (odds ratio [OR], 1.23, 95 percent confidence interval [CI], 1.09‒1.38). [bipolar disorder](https://specialty.mims.com/bipolar%20disorder/treatment), major [depression](https://specialty.mims.com/depression/treatment), and [schizophrenia](https://specialty.mims.com/schizophrenia/treatment) are predictive of episode polarity and psychotic symptoms in a similar manner among individuals with bipolar disorder, suggests a recent study. Polygenic risk scores (PRS) for

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