DNA

2022 - 12 - 27

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Image courtesy of "Genetic Engineering & Biotechnology News"

DNA Origami Adds Multilayered Curved Shapes to its Catalog (Genetic Engineering & Biotechnology News)

DNA origami, a fascinating technology that uses algorithms to design self-assembling 2- and 3D nanostructures using DNA helices, has added a new member to ...

The key to designing stable DNA nanostructures is the placement of short DNA “staples” that hold the longer DNA coils together. The researchers have co-opted the principles of complementarity inherent in DNA bases to design specific DNA sequences that “program” the strands to self-assemble into different shapes. Designing capsules within capsules, like a Russian doll, using DNA, requires the ability to bend and fold long threads of DNA helices into complex 3D shapes with nanoscale precision. Advances in design strategies proposed the use of curved DNA helices that were better suited to generate capsule-like structures that align more closely with natural globular molecules while retaining enclosed spaces for compartmentalized molecular interactions. [Automated Design of 3D DNA Origami With Non-Rasterized 2D Curvature”](https://dx.doi.org/10.1126/sciadv.ade4455)). The ability to design layered and curved geometries could be a game changer for nanofabrication, molecular signaling, medical imaging, and drug delivery.

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Image courtesy of "Laboratory Equipment"

Study: Clues to DNA Packing Can Help Better Target Cancer Cells (Laboratory Equipment)

They were surprised to find DNA packing was delayed when HDAC1 was inhibited. Targeting HDAC proteins with selective inhibitors can aid in creating more ...

“These selective inhibitors are a great way to target cancer cells,” said Long. First, the extract system used in Long’s lab is novel and can be used to answer questions that are difficult to address using traditional cell or animal models. This surprised the researchers, leading them to explore further how HDAC1 interacts with different proteins than HDAC2 to complete its job.

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Image courtesy of "Phys.Org"

Functional analyses of RNA-related enzymes using a next ... (Phys.Org)

Genetic information encoded in genomic DNA is transcribed to mRNAs and then the codons on mRNA are decoded by transfer RNAs (tRNAs) during protein synthesis ...

[enzyme](https://phys.org/tags/enzyme/). Thus, tRNA-Map can accelerate the integrative understanding of the flow of [genetic information](https://phys.org/tags/genetic+information/). Furthermore, they analyzed the substrate recognition mechanism of G. tRNAs contain numerous modified nucleosides, which regulate the accuracy and efficiency of protein synthesis. tRNAs deliver amino acids to ribosomes and proteins are synthesized from the amino acids on the ribosomes according to the decoded genetic information. Genetic information encoded in genomic DNA is transcribed to mRNAs and then the codons on mRNA are decoded by transfer RNAs (tRNAs) during protein synthesis.

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Image courtesy of "ASU Now"

Ahead of the curve: New techniques advance DNA nanotech (ASU Now)

In a new study, Professor Hao Yan from Arizona State University, Professor John Reif from Duke University and their colleagues describe a technique for ...

Using bundles of DNA helices in the design process, the researchers were able to exert fine-grained control over both concave and convex curvatures, compared with conventional block-based designs. The computer-guided, curved DNA helices enable researchers to more accurately approximate nature’s astonishing variety and geometric ingenuity. The curved DNA nanostructures were assembled and imaged by students [Raghu Pradeep Narayanan](https://scholar.google.com/citations?user=DuZDOhMAAAAJ&hl=en) and [Abhay Prasad](https://scholar.google.com/citations?user=YcLIOjgAAAAJ&hl=en) in Yan’s lab at ASU. Multilayer designs combined with targeted reinforcement of these structures prevent structural disintegration or collapse, even under conditions of high strain and curvature. Although the technique has proven highly versatile, some nanoforms are exceptionally difficult to design and fabricate, involving time-consuming and tedious trial and error, as many variables can adversely affect proper self-assembly. DNA origami has been used to create forms of aesthetic beauty as well as those of importance for biomedical, computer and electronic device applications. Composing such forms using traditional DNA origami methods is taxing and unreliable, often resulting in inaccurate or failed structures. He has just been elected to the rank of [NAI Fellow by the National Academy of Inventors](https://mailchi.mp/academyofinventors/nai-announces-2022-fellows). DNA nanotechnology is a rapidly evolving field, thriving in the borderlands between biology and chemistry. The delicate nanoarchitectures are so small, some 50,000 of them could comfortably rest on the head of a pin. The method allows researchers to produce tiny structures displaying curvatures and asymmetries that are difficult or impossible to create using conventional approaches. These and many other infinitesimal architectures can be visualized using sophisticated techniques like transmission electron microscopy.

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Image courtesy of "Nature.com"

Prediction of designer-recombinases for DNA editing with ... (Nature.com)

While effective, directed molecular evolution methods are laborious and time consuming. Here we present RecGen (Recombinase Generator), an algorithm for the ...

[2b](/articles/s41467-022-35614-6#Fig2)). [5b](/articles/s41467-022-35614-6#MOESM1)). [5a](/articles/s41467-022-35614-6#MOESM1)). [2f](/articles/s41467-022-35614-6#Fig2)). [2d](/articles/s41467-022-35614-6#Fig2)). [2a](/articles/s41467-022-35614-6#MOESM1), [4b](/articles/s41467-022-35614-6#MOESM1)). [2a](/articles/s41467-022-35614-6#Fig2)). [2c](/articles/s41467-022-35614-6#MOESM1)). [2b](/articles/s41467-022-35614-6#MOESM1)). [1c](/articles/s41467-022-35614-6#MOESM1)). [1](/articles/s41467-022-35614-6#MOESM1)). [1](/articles/s41467-022-35614-6#ref-CR1)).

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Image courtesy of "The Daily News of Newburyport"

Prosecutor: McClendon's DNA matched samples from murdered girl ... (The Daily News of Newburyport)

Murder suspect Marvin “Skip” McClendon sits at the defense table in Salem Superior Court for a motion to dismiss hearing Tuesday. JILL HARMACINSKI/Staff photo.

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Image courtesy of "GoErie.com"

Pa. Supreme Court to hear DNA-focused appeal over conviction in ... (GoErie.com)

State's highest court is stepping in after an Erie County judge and state Superior Court rejected the arguments of defendant, Willie James Hardy.

Other key evidence included Hardy's interview with Erie police, in which he gave conflicting accounts of what happened the night of the murder and was unable to account for 15 minutes of his time that night. The Superior Court ruling accepted the arguments of the District Attorney's Office, which said Hardy's request was a "Hail Mary" attempt to point attention away from what the office described as "substantial evidence of guilt." Hardy wanted to test some evidence for the first time and retest other evidence that was already examined for DNA before he was convicted. However, the Superior Court said, Hardy failed to show how results of the new DNA tests would be any different than the old tests, which did not clear him and which were not even a focus of his trial defense. In the DNA case, the Superior Court affirmed a March 2021 ruling from Erie County Judge Daniel Brabender, who found that Hardy failed to meet the standards under the 2002 state law that allows for post-conviction DNA testing. and midnight the night she was found dead in her car near the plant. 1, according to the schedule the Supreme Court set. The District Attorney's Office will also get a chance to brief the case, and the state Supreme Court is expected to schedule oral arguments. In its unanimous decision, a three-judge panel of the state Superior Court reviewed those three issues and rejected Hardy's arguments. Another jury convicted Hardy of first-degree murder in 1996, and he lost all his appeals over that conviction. The Supreme Court's decision to grant what is known as The state Supreme Court said on Dec.

DNA can determine if you're a morning person or night owl: Study (Canada.com)

When it comes to ancestry, there are things influenced by DNA that can tell a person more of the things you wouldn't think to look for.

Though it should be noted that the feature is not intended to help people diagnose potential health conditions. Meanwhile, 66% of Canadians know that DNA can impact a person’s ability to remember their dreams, but were you aware it also impacts the scent of one’s urine after eating asparagus? Article content

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Image courtesy of "Ars Technica"

NatureMetrics launches biodiversity platform based on ... (Ars Technica)

NatureMetrics creates kits to check for environmental DNA (eDNA) in an area, which should indicate the species present. According to Critchlow, these kits are ...

The kits allow companies to check the relative abundance of species in an area. Mining company Anglo American is expressing interest in the service, Critchlow said. A mining company could use it to check for endangered species in a site they hope to work in or use it several times over a year to see how biodiversity is changing in the area, for instance. Critchlow noted that the kits don’t enable users to get an exact population size, but they can tell users which species are more common than others in an area. The company is in the early stages of launching a subscription service that lets corporations regularly check their sites for biodiversity and keep an eye on any changes—good or bad—their activities have. NatureMetrics creates kits to check for environmental DNA (eDNA) in an area, which should indicate the species present.

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Image courtesy of "Nature.com"

RNaseH2A downregulation drives inflammatory gene expression ... (Nature.com)

Cellular senescence caused by oncogenic stimuli is associated with the development of various age-related pathologies through the senescence-associated ...

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DNA can determine if you're a morning person or night owl: Study (Toronto Sun)

When it comes to ancestry, there are things influenced by DNA that can tell a person more of the things you wouldn't think to look for.

Though it should be noted that the feature is not intended to help people diagnose potential health conditions. Meanwhile, 66% of Canadians know that DNA can impact a person’s ability to remember their dreams, but were you aware it also impacts the scent of one’s urine after eating asparagus? Article content

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