BMI

1. In adolescents with obesity, semaglutide plus lifestyle intervention resulted in a significant body mass index (BMI) reduction compared to lifestyle ...

Overall, this study found that in adolescents with obesity, once-weekly semaglutide in addition to a lifestyle intervention resulted in a substantial reduction in BMI as compared with lifestyle intervention alone. Patients who were adolescents (12 to 17 years of age) with a BMI in the 95th percentile or higher (according to sex and age-specific growth charts) and those with a BMI in the 85th percentile or higher who had at least one weight-related coexisting condition with at least one unsuccessful dietary weight loss effort were eligible for the study. [2 Minute Medicine, Inc](http://www.2minutemedicine.com). Reductions in body weight and improvement with respect to cardiometabolic risk factors (waist circumference and levels of glycated hemoglobin, lipids, and alanine aminotransferase) were greater with semaglutide than with placebo. Nevertheless, the study’s findings demonstrate that once-weekly semaglutide provides a significant reduction in BMI compared with lifestyle modification alone. However, there is a gap in knowledge as to understanding whether once-weekly semaglutide plus lifestyle intervention is effective among adolescents with obesity.