Melatonin

Melatonin, a hormone that regulates our body's circadian rhythms, is synthesized at night by the pineal gland. As a dietary supplement, it is not regulated ...

European Journal of Pharmacology 907: (article 174365, 13 pages), 2021. Modulation of the tumor microenvironment (TME) by melatonin. Frontiers in Pharmacology 13 (article 947117), 2022. International Journal of Molecular Sciences 23: 1238 (23 pages), 2022. In most countries, melatonin requires a prescription (Kuehn). Melatonin reportedly has a role in the treatment of osteoporosis (López-Muñoz et al., 2022). [circadian rhythms](https://www.psychologytoday.com/us/basics/circadian-rhythm), light is the strongest “timekeeper" (Walker et al.). It has raised safety concerns, especially with long-term use in certain populations like children and adolescents (Kuehn, July 2022). This pool, which does not exhibit a circadian rhythm, may be a "critical factor" in the optimal functioning of mitochondria (Reiter et al., 2022). Furthermore, it has major anti-cancer effects: it is oncostatic, namely—it can suppress cancer growth in some tumors and even suppress the development of metastases (Reiter et al., 2021a; Mu and Najafi, 2021). Furthermore, since animals in the wild experience some light from the moon or stars, creating an extremely dark environment may not mimic nature (Aulsebrook et al., 2022). Our built-in master clock, the suprachiasmatic nucleus (SCN) in our anterior hypothalamus, regulates this system.