Sepsis

2022 - 6 - 26

Post cover — Image courtesy of "Michigan Medicine"

Antibiotic use and sepsis make recent improvements (Michigan Medicine)

In 152 hospitals, efforts to treat sepsis faster have not resulted in antibiotic overuse. hospital beds crowded different patients white background and beds.

Subscribe to the Michigan Health Lab blog newsletter “The pushback has been [time-to-treatment for sepsis] should not be a performance measure because it’s going to cause more harm than good, and I think our data shows it probably does more good than harm,” Prescott said. About half of the people who met the criteria for SIRS received antibiotics within 12 to 48 hours after admission, a practice that decreased slightly over time. “We showed in the overall cohort, that antibiotic use decreased. Hospitals and policymakers alike have banded together to improve recognition and treatment of sepsis, a life-threatening reaction to infection, which by some estimates, accounts for 30-50% of all deaths in hospitalized patients. Patients included came to the emergency department with signs of systemic inflammatory response syndrome (SIRS), which includes increased heart rate, abnormal body temperature, among other signs.

Intravenous vitamin C increases mortality and organ dysfunction in ... (Physician's Weekly)

1. In patients with sepsis receiving a vasopressor in the intensive care unit (ICU), intravenous vitamin C was associated with a higher risk of death and ...

Overall, the trial demonstrated that for patients with sepsis admitted to the ICU who were on vasopressor therapy, intravenous vitamin C was associated with a higher risk of death or persistent organ dysfunction. The present randomized, placebo-controlled trial sought to study the effects of high-dose intravenous vitamin C in adults with sepsis on vasopressor therapy in the ICU. Compared to placebo, vitamin C was associated with a higher composite risk of death or persistent organ dysfunction at 28 days. In-Depth [randomized controlled trial]: This phase three, double-blind randomized controlled trial investigated the effect of intravenous high-dose vitamin C in patients with sepsis admitted to the ICU. Adult patients who had stayed in the ICU for less than 24 hours with proven or suspected sepsis, and who were receiving a vasopressor were included. Despite a small number of patients not contributing data following randomization, the study showed evidence of harm from intravenous vitamin C in sepsis patients in the ICU. The primary outcome occurred in 44.5% of vitamin C recipients and 38.5% of the control group (Risk Ratio [RR], 1.21; 95% Confidence Interval [CI], 1.04 to 1.40; p=0.01). At 28 days, 35.4% of the patients in vitamin C and 31.6% of patients in the control group had died (RR, 1.17; 95% CI, 0.98 to 1.40), while persistent organ dysfunction occurred in 9.1% and 6.95% of the patients in each group, respectively (RR, 1.30; 95% CI, 0.83 to 2.05). Both groups also had comparable safety outcomes. Overall, 872 patients underwent randomization (435 in the vitamin C group and 437 in the control group). Vitamin C at 50mg per kilogram body weight or matched placebo were given every 6 hours for up to 96 hours.

Early antibiotics for sepsis supported in new study – NCAL ... (Kaiser Permanente Division of Research)

Concerns about overuse of antibiotics in hospitalized patients addressed in multi-hospital analysis that included Kaiser Permanente. By Jan Greene.

“The pushback has been [time-to-treatment for sepsis] should not be a performance measure because it’s going to cause more harm than good, and I think our data shows it probably does more good than harm,” Prescott said. At the same time the hospitals were improving care for sepsis patients, they were not indiscriminately expanding antibiotic use with others, the analysis found. “There has been an intense focus on treating sepsis patients with antibiotics as early as possible because it is the cornerstone of performance improvement for this devastating condition,” Liu said.

Efforts to treat sepsis faster have not resulted in antibiotic overuse (Medical Xpress)

Hospitals and policymakers alike have banded together to improve recognition and treatment of sepsis, a life-threatening reaction to infection, ...

"The pushback has been [time-to-treatment for sepsis] should not be a performance measure because it's going to cause more harm than good, and I think our data shows it probably does more good than harm," Prescott said. About half of the people who met the criteria for SIRS received antibiotics within 12 to 48 hours after admission, a practice that decreased slightly over time. Hospitals and policymakers alike have banded together to improve recognition and treatment of sepsis, a life-threatening reaction to infection, which by some estimates, accounts for 30–50% of all deaths in hospitalized patients.

Intravenous vitamin C increases mortality and organ dysfunction in ... (2 Minute Medicine)