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Hallucinogenic mushrooms have shown promise for their medical benefits, but we are only now beginning to understand how they might help to treat depression.

The brains of people taking escitalopram, on the other hand, showed no change in connectivity between the default mode and other brain networks six weeks after treatment started. Regardless of the caveats, these studies are incredibly promising and move us closer to expanding the available treatment options for patients with depression. And we know that patients with higher levels of negative rumination tend to show increased activity of the default mode network compared with other networks at rest – literally becoming less responsive to the world around them. An active connection between these two brain areas is normally a feature of the brain's " default mode network". This network is active when we rest and focus internally, perhaps reminiscing about the past, envisioning the future or thinking about ourselves or others. Previous studies, using functional MRI (fMRI) brain scanning, have shown that psilocybin seems to reduce activity in the medial prefrontal cortex, an area of the brain that helps regulate a number of cognitive functions, including attention, inhibitory control, habits and memory. So there is an urgent need to expand the repertoire of drugs available to people with depression.

The pearlescent tribute to William Collins, which has a solar-powered jukebox, was installed at Sheffield's Shiregreen Cemetery in March. Sheffield City Council ...

Since it was erected, the council said it had tried to contact the family to "discuss the matter". However, ten weeks after the monument was installed, the council said it had no update to share as it continued to reach out to the family. A huge marble memorial to a late father-of-nine remains unchanged months after the council wrote to the family to discuss the monument.

Former footballer Colin Gibson has urged people to get tested after being diagnosed with early-onset dementia. Mr Gibson, 62, part of the Aston Villa team ...

A neuropathologist said Mr Astle died of a brain condition normally linked to boxers and caused by heading footballs. but you can slow it down." "There is a lot of stigma to it, a lot of people put their head in the sand and the sooner we can get something done about dementia, I know there is never going to be a cure...

Coldstream Guardsman Mathew Talbot, from Great Barr, suffered fatal injuries during an anti-poaching patrol in May 2019. His family has worked with staff at ...

She added: "We were all so moved by the story that we wanted to have him here with us all of the time." "The thought that the children here, where Matt was happy, are going to carry on with his memory is just wonderful," Mrs Talbot said. The 22-year-old, who "loved the Army", was part of a five-man mixed Malawian and British group and on his first operational tour when he was attacked.

Essex Police discovered Cristian-Marin Patru, 24, with injuries to his neck, chin and back in Harlow on 8 November. Jayden Drake, 25, of Maclean Road, ...

Essex Police said officers believed Drake had been using the property, in The Hides, as part of his drug dealing activities, and that he had a history of carrying knives. Two men have been found guilty of murdering a man who was found with fatal stab wounds at a house police believe was a drugs den. Two found guilty of 'brutal and senseless' murder in Harlow

The Scottish-born musician was due to perform on the 9, 15 and 18 June at the Aldeburgh Festival in Suffolk. Organisers said they hoped Benedetti would be able ...

Organisers said they were "very grateful" to Christian Tetzlaff for stepping in to perform on 9 June at Snape Maltings Concert Hall, and Elena Urioste would replace Benedetti on 15 and 18 June at Blythburgh Church. The Scottish-born musician was due to perform on the 9, 15 and 18 June at the Aldeburgh Festival in Suffolk. Violinist Nicola Benedetti has cancelled three of her performances at a festival due to tendonitis in her wrist.

Annie Skinner found the envelope containing £3800 when she ran over it with her shopping trolley.

Annie, and others who choose to follow the same actions, should be recognised by the community for these responsible acts." Ms Skinner said: "When I saw the envelope on the floor, I thought it was a balloon and I pushed my shopping trolley over it to pop it. Officers delivered a box of chocolate to Ms Skinner for being an "amazing lady", while the owner of the cash rewarded her with money and flowers.

The steam engine was towing a caravan, a 4x4 and a trailer at 5mph on the A47 in Norfolk.

The locomotive was pulling a vintage caravan, which was towing a Land Rover Discovery, which in turn was towing a twin-axle trailer. The engine was towing a vintage caravan, a 4x4 and a trailer on the A47 near Trowse, Norfolk, on Monday. The driver of a traction engine towing a long load was pulled over after holding up traffic at 5mph (8km/h) on a busy main road.

Gavin Rawson died trying to save Nathan Walker, whose son was born just days after he drowned.

- Stewart Brown, 69, of Fernwood Close in Mansfield, Nottinghamshire, was found guilty of failing to ensure the health and safety of his co-workers. Mrs Leivers and her husband Ian Leivers, 59, of Fosse Road, Newark, were convicted of allowing Greenfeeds to commit this offence. "Nathan's death was cruel and there was no sense in it. "Nathan was expecting his first child with his partner when he died. - The company had already pleaded guilty to failing to ensure the health and safety of its employees. The men were released after a saw was used to cut holes in the side of the tanker.

On a remote island deep into the Arctic Circle, a passionate jazz musician runs a hospitality project like no other – and it takes all his improvisational ...

"We're in the middle of enormous longing for nature and a deep need for a place like this," he said. But founding decision-making on economic terms in this space is like comparing jazz with classical music, according to the musician, who sees improved mental health and a strengthened connection with nature as the greatest gifts this space can offer. For many, this self-sufficiency and simplicity is part of the appeal, and the hotel attracts like-minded people happy to join in and help. The result is a new outlook on what a hotel space can be and achieve. Every aspect is calculated to put you more in touch with the extraordinary surroundings. Sleeping cabins are designed to fit a bed and not much else; the idea is that you have what you need, but no more, so your focus is more fully on nature. In the meantime, maybe you'll discover a treasure trove of sea urchin shells discarded by otters on a walk around the island. The experience helped him realise that once you leave specific industry language behind, we can all help each other in unexpected ways – and that there should be a place for it in the world. It's the setting for a singular type of experience, where guests make an arduous trek to experience nature in the raw, find respite from burnout and discover the value of collaboration between unlikely disciplines. Lund believes that when sequestered in nature, the experience becomes about the community you build, the new perspectives you discover and the clarity of thinking you can recover. Once they're here, it's all about the simple things: exploring the nearby uninhabited islands; watching otters play along the shore; and witnessing orca teaching their young to hunt in the bay. Tethered to windswept rocks on an island deep into the Arctic Circle is an unexpected sight: a tiny hotel with just four modernist sleeping cabins.

A new map traces the shape of the remote ocean bed surrounding Antarctica.

There's high hope that an emerging class of robotic vessels could be given this task in the years ahead. Water piles up over the mass of a large submarine mountain and dips slightly where there is a trench. "There's a record of where the ice flowed and where its grounded zones (places in contact with the seafloor) extended. It's a depression called Factorian Deep at the far southern end of the South Sandwich Trench. It lies 7,432m down. This is information required to improve the models that forecast future climate change - because it is the oceans that play a pivotal role in moving heat around the planet. The UK's new polar ship, the RRS Sir David Attenborough, is equipped to map millions of sq km of ocean bottom over its career.