The aging transition of menopause, unique to women, is a process that dismantles both reproductive ability and, potentially, the bioenergetic capacity in the ...
Dr. Brinton, who is a member of the BIO5 Institute, received the initial five-year award of $1.5 million in 2017. From a discovery perspective, this research is unique in exploring the mechanisms underlying nuclear and mitochondrial gene expression in the aging female brain. Understanding how estrogen acts to promote and sustain the brain’s energy-producing system is critical to revealing changes that can increase the risk of age-associated neurodegenerative diseases including Alzheimer’s disease in postmenopausal women.